Jpn. J. Appl. Phys. 43 (2004) pp. 1685-1689  |Previous Article| |Next Article|  |Table of Contents|
|Full Text PDF (379K)| |Buy This Article|

Three-Dimensionally Stacked Analog Retinal Prosthesis Chip

Jun Deguchi, Taiichiro Watanabe, Tomonori Nakamura, Yoshihiro Nakagawa, Takafumi Fukushima, Shim Jeoung-Chill, Hiroyuki Kurino, Toshiaki Abe¹, Makoto Tamai¹ and Mitsumasa Koyanagi

(Received October 1, 2003; accepted January 23, 2004; published April 27, 2004)

As blind patients with an intact optic nerve and damaged photoreceptor cells increase in number in recent years, there has been a growing interest in visual prostheses by electrically stimulating their retinas. Previous clinical studies indicated that blind patients perceive a controlled electrical current applied to a small area of the retina via electrodes as a spot of light. We propose a novel implantable device, so-called three-dimensionally (3D) stacked retinal prosthesis, which is composed of a photodetector, an image processor, electrical current generator circuits, and an electrode array on one chip. The spice simulation showed that our designed analog circuits for 3D stacked retinal prosthesis chip could output desirable electrical current with variable pulse width by controlling bias voltages.

URL: http://jjap.jsap.jp/link?JJAP/43/1685/
DOI: 10.1143/JJAP.43.1685

References | Citing Articles (16)

1. W. Liu, K. Vichienchom, M. Clements, S. C. DeMarco, C. Hughes, E. McGucken, M. S. Humayun, E. de Juan, J. D. Weiland and R. Greenberg: IEEE J. Solid-State Circuits 35 (2000) 1487.
2. R. Eckmiller: Ophthalmic Res. 29 (1997) 281.
3. E. Zrenner, A. Stett, S. Weiss, R. B. Aramant, E. Guenther, K. Kohler, K.-D. Miliczek, M. J. Seiler, H. Haemmerle: Vision Res. (1999) 2555.
4. A. Y. Chow and N. S. Peachey: Ophthalmic Res. (1998) 195.
5. J. Rizzo, J. Loewenstein and J. Wyatt: Retinal Degenerative Diseases and Experimental Theory (Kluwer Academic/Plenum Publishers, 1999) p. 463.
6. T. Yagi, Y. Ito, H. Kanda, S. Tanaka, M. Watanabe and Y. Uchikawa: Proc. 1999 IEEE Int. Conf. Systems, Man, & Cybernetics 4 (1999) 382.
7. M. S. Humayun, E. de Juan Jr., J. D. Weiland, G. Dagnelie, S. Katona, R. Greenberg and S. Suzuki: Vision Res. 39 (1999) 2569.
8. M. S. Humayun, E. de Juan Jr., G. Dagnelie, R. J. Greenberg, R. H. Propst and H. Phillips: Arch. Ophthalmol. 114 (1996) 40.
9. R. Greenberg: Ph.D. Dissertation, The Johns Hopkins University, Baltimore, MD, 1998.
10. J. Wyatt and V. Chow: IEEE Spectrum (1996) 47.
11. A. Y. Chow and V. Y. Chow: Neurosci. Lett. 225 (1997) 13.
12. R. Eckmiller: Ophthalmic Res. 29 (1997) 281.
13. E. Zrenner, K.-D. Miliczek, V. P. Gabel, H. G. Graf, E. Guenther, H. Haemmerle, B. Hoefflinger, K. Kohler, W. Nisch, M. Schubert, A. Stett, S. Weiss: Ophthalmic Res. 29 (1997) 269.
14. H. Kurino, Y. Nakagawa, T. Nakamura, Y. Yamada, K. W. Lee and M. Koyanagi: IEICE Trans. Electron. E84-C (2001) 1717.
15. K. W. Lee, T. Nakamura, T. Ono, Y. Yamada, T. Mizukusa, H. Hashimoto, K. T. Park, H. Kurino and M. Koyanagi: Int. Electron Device Meet. (2000) p. 165.
16. H. Kurino, K. W. Lee, T. Nakamura, K. Sakuma, K. T. Park, N. Miyakawa, H. Shimazutsu, K. Y. Kim, K. Inamura and M. Koyanagi: Int. Electron Device Meet. (1999) p. 879.