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Jpn. J. Appl. Phys. 45 (2006) pp. L1334-L1336  |Previous Article| |Next Article|  |Table of Contents|
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Letter

Noise Analysis of Si-Based Planar-Type Ion-Channel Biosensors

Hidetaka Uno¹, Zheng Long Zhang², Mitsukazu Suzui¹, Ryugo Tero^1,2, Youichi Nonogaki^1,2, Satoshi Nakao¹, Shu Seki³, Seiichi Tagawa³, Shigetoshi Oiki⁴ and Tsuneo Urisu^1,2

¹Institute for Molecular Science, Myodaiji, Okazaki, Aichi 444-8585, Japan
²The Graduate University for Advanced Studies, Myodaiji, Okazaki, Aichi 444-8585, Japan
³The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan
⁴Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan

(Received August 29, 2006; accepted November 4, 2006; published online December 15, 2006)

A micropore with a diameter of 50–100 µm was formed, which penetrated a silicon on insulator (SOI) substrate and a Teflon substrate. The single-ion-channel current of gramicidin A (g-A) was measured for the planar lipid bilayer with reconstructed g-A formed in this micropore. The background noise in the SOI substrate was almost at an equivalent level to that in the Teflon substrate. It can be concluded from the noise analysis that a noise characteristic of the same level as that of the Teflon substrate or the glass substrate can be achieved for the Si substrate by controlling the substrate structure in the vicinity of the micropore with a wide range of pore diameters.

URL: http://jjap.jsap.jp/link?JJAP/45/L1334/
DOI: 10.1143/JJAP.45.L1334

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References | Citing Articles (4)

1. W. Thomsen, J. Frazer and D. Unett: Curr. Opin. Biotechnol. 16 (2005) 655.
2. X. Li, K. G. Klemic, M. A. Reed and F. J. Sigworth: Nano. Lett. 6 (2006) 815[CrossRef].
3. H. Suzuki, K. V. Tabata, H. Noji and S. Takeuchi: Langmuir 22 (2006) 1937.
4. N. Fertig, M. Klau, M. George, R. H. Blick and J. C. Behrends: Appl. Phys. Lett. 81 (2002) 4865[AIP Scitation].
5. M. Mayer, J. K. Kriebel, M. T. Tosteson and G. M. Whitesides: Biophys. J. 85 (2003) 2684.
6. W. F. Wonderlin, A. Finkel and R. J. French: Biophys. J. 58 (1990) 289.
7. R. A. Levis and J. L. Rae: Methods Enzymol. 293 (1998) 218.
8. S. J. Wilk, M. Goryll, G. M. Laws, S. M. Goodnick, M. Saraniti, J. Tang, R. S. Eisenberg and T. J. Thornton: Appl. Phys. Lett. 85 (2004) 3307[AIP Scitation].
9. J. Kutchinsky, S. Friis, M. Asmild, R. Taboryski, S. Pedersen, R. K. Vestergaard, R. B. Jacobsen, K. Krzywkowski, R. L. Schroder, T. Ljungstrom, N. Helix, C. B. Sorensen, M. Bech and N. J. Willumsen: Assay Drug Dev. Technol. 5 (2003) 685.

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