Jpn. J. Appl. Phys. 47 (2008) pp. 7415-7419  |Previous Article| |Next Article|  |Table of Contents|
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A Hybrid Three-Dimensional Nanofabrication Method for Producing Vascular Tissue Engineering Scaffold

Nikolaj Gadegaard, Kris Seunarine, David J. A. Smith¹, David O. Meredith, Chris D. W. Wilkinson, and Mathis O. Riehle

(Received November 16, 2007; revised April 30, 2008; accepted June 12, 2008; published online September 12, 2008)

There is a trend towards the production of lithographically defined materials for biological applications. The field of nanobio technology is rapidly growing and so is demand for materials nanostructured in three dimensions. Here we present a hybrid approach where we use electron beam lithography, photolithography and hot embossing to produce membranes patterned on both sides. The double sided patterned membranes were subsequently rolled to create the three dimensional tissue construct aimed at vascular repair. The mechanical properties such as bending and bursting pressure were also investigated.

URL: http://jjap.jsap.jp/link?JJAP/47/7415/
DOI: 10.1143/JJAP.47.7415
KEYWORDS:embossing, imprint lithography, 3D, electron beam lithography, polymer phase separation

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